Eriocalyxin B relieves kidney damage in a rat model of membranous nephropathy by inhibiting JAK/STAT3 pathway
نویسندگان
چکیده
Purpose: To investigate the function of eriocalyxin B (EriB) in membranous nephropathy (MN) a rat model and related mechanisms.
 Methods: Cationic C-BSA was injected into Sprague-Dawley (SD) rats to generate MN. The MN were treated with different concentrations EriB (2.5, 5, 10 mg/kg). After treatment, their kidneys excised, sectioned, hematoxylin eosin (H&E) stained determine renal injury, while Masson's trichrome staining performed tissue fibrosis. Bradford assay used proteinuria ELISA employed blood urea nitrogen (BUN) serum creatinine (SCr) levels. also measure IL-1β, IL-6, TGF-α levels, immunoblot analysis assess protein expressions indicators JAK/STAT3 pathway.
 Results: Compared sham rats, showed increased contents proteinuria, BUN, SCr (p < 0.01), induced serious expression collagen I III It elevated levels causing inflammation activation pathway. treatment alleviated fibrosis, rats. With increase concentration, injury gradually alleviated.
 Conclusion: alleviates by inhibiting Thus, is potential drug for management
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2023
ISSN: ['1596-5996', '1596-9827']
DOI: https://doi.org/10.4314/tjpr.v22i1.10